NĒRx-3392

NĒRx-3392 (Ku inhibitor): Lead compound that demonstrates strong inhibition of the interaction between Ku and DNA, providing a novel mechanism for inhibiting DNA-PK activity. Inhibitors that target Ku enhance cellular sensitivity to radiation treatment and to DNA double-strand break-inducing chemotherapeutic agents such as etoposide and bleomycin. Proof-of-concept in vivo data indicates efficacy in non-small cell lung cancer (NSCLC) xenograft models when combined with radiation therapy.